【前沿】p63可表达于高风险弥漫大B细胞淋巴瘤

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Protein expression in high risk diffuse large B-cell lymphoma
J Clin Pathol 2009;62:77–79.

p63常常在外检诊断中用作低分化癌的标记（尿路上皮癌、鳞癌），但需要引起注意的是，p63也可表达于一些大细胞淋巴瘤中。

膀胱DLBCL，p63阳性

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Take-home messages

A p53 gene homologue (p63) was described recently and some authors related it to poor prognosis in malignant lymphoma. A study from Japan showed expression of p63 protein in 34% of cases with poor overall survival.

Few studies have investigated the prognostic significance of p63 in diffuse large B-cell lymphoma (DLBCL), especially in high–intermediate and high risk populations.

The expression of p63 has been **ysed in high–intermediate and high risk DLBCL; p63 expression was observed in 15.1% of cases, lower than the literature. p63 Had a protective effect on high–intermediate and high risk DLBCL.

冰**心

请教斑竹，有些单词不会翻译（如take-message如何翻译）



    一些作者近来发现P63基因与恶性淋巴瘤的预后相关，一项来自日本的研究显示34%的P63基因表达于整体生存贫困人口。
    少数研究显示P63在弥漫性大B细胞瘤的表达具有预后意义，特别是对于中高级和高风险人群。
    分析P63在中高及高风险人群的表达：P63阳性占15.1%，低于文献；P63阳性表达者对中高及高级淋巴瘤有保护作用