nature06年4月10号 癌症版 proten-typrosine phosphatases and cancer

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Protein-tyrosine phosphatases and cancer
Ostman A, Hellberg C, Bohmer FD
Abstract: Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (**s). Recent evidence has shown that **s can function as tumour suppressors. In addition, some **s, including SHP2, positively regulate the signalling of growth-factor receptors, and can be oncogenic. An improved understanding of how these enzymes function and how they are regulated might aid the development of new anticancer agents.

[ 本帖最后由 pathology 于 2006-5-5 23:14 编辑 ]