乳腺癌Her-2基因扩增标准-2010

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Abstract
The invasive mammary cancer is the most frequent malignant tumor of women. Different inherited or acquired molecular genetic
alterations have been identified in human breast cancers. A fraction of these cancers, as part of their development, undergoes  gene
amplification. Among the potential prognostic factors are included the biomarkers which measure or are associated with biologic al
processes involved in tumor progression. Evaluation of HER-2 status is important in the management of patients with breast carc inoma,
especially for the identification of those who are eligible for immunotherapy. The aim of our study was to evaluate HER-2 ampli fication
status of human breast cancers by FISH and immunohistochemistry. From the total of 50 tumors included in the study, 17 (34%) pr esented
different degrees of positivity; 33 (66%) did not express the onc oprotein HER-2. HER-2 gene and chromosome 17 status were tested in
HER-2 2+ cases using FISH technique. FISH **ysis may be useful to better evaluate HER-2 status in breast cancer in uncertain  cases,
where the immunohistochemistry score is 2+. HER-2 testing results have an important role in the clinical management of breast cancer
patients. The identification of HER-2 positive tumors is certainly crucial in order to identify patient candidates for anti-HER -2 therapies.
Keywords :  breast cancer, HER-2 protein, HER-2 gene amplification, immunohistochemistry, FISH technique.

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