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Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease
Written by Pirjo Nuutila
Metabolism
Decrease in adiponectin level, a common feature in patients with type 2 diabetes mellitus, is considered to predict cardiovascular events. Elevated oxidized low-density lipoprotein (oxLDL), formed within the arterial wall, is commonly seen as part of the atherogenic profile. We investigated the ass
Neonatal streptozotocin-induced diabetes mellitus: a model of insulin resistance associated with loss of adipose mass
Written by Fabio Bessa Lima
Metabolism
The use of experimental models of diabetes mellitus (DM) has been useful in understanding the complex pathogenesis of DM. Streptozotocin (STZ) injected in rats during the neonatal period has usually led to the major features described in diabetic patients (hyperglycemia, polyphagia, polydipsia, pol
Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects
Written by Jian Rong Han
Metabolism
Prior studies of medium-chain triglyceride (MCT) suggest that MCT might be a useful tool for body fat mass management in obese nondiabetic humans. We now report a pilot study that tests if MCT is beneficial for moderately overweight subjects with type 2 diabetes mellitus. The study was conducted in
Management of necrotizing fasciitis in diabetic patients
Written by Ali G眉rlek
Journal of Diabetes and Its Complications
Necrotizing fasciitis is a life-threatening condition in diabetic patients; its management and salvage of the patient is a formidable challenge. Diabetes mellitus is one of the serious conditions associated with necrotizing fasciitis. It is a disorder that primarily affects the microvascular circul
Health-related quality of life among patients with diabetes and foot ulcers: association with demographic and clinical characteristics
Written by Lis Ribu
Journal of Diabetes and Its Complications
Objective The purpose of the study was to describe the sociodemographic variables, clinical characteristics, and treatment factors in patients with diabetic foot ulcers (DFU) and to explore the associations between these factors and the patients' health-related quality of life (HRQL). Materia
Transition to insulin in Type 2 diabetes: family physicians' misconception of patients' fears contributes to existing barriers
Written by Shlomo Vinker
Journal of Diabetes and Its Complications
Background Many patients with Type 2 diabetes require treatment with insulin but do not receive it. Aim To examine the barriers that hinder the transition to insulin from the point of view of patients and family physicians. Methods Patients: Study group (SG)?"92 patients who need insulin (max
Improving metabolic control in sub-optimally controlled subjects with Type 1 diabetes: Comparison of two treatment algorithms using insulin glargine
Written by Ramon Gomis
Diabetes Research and Clinical Practice
This study assessed the incidence of severe hypoglycaemia with two insulin glargine titration algorithms: Algorithm 1 (increments of at least 10%, but not exceeding 4 U) versus Algorithm 2 (1-6 U increments). In this multicenter (n = 409), multinational (n = 54), open-label, 24-week randomized tria
Undertreatment of cardiovascular risk factors among persons with diabetes in the United States
Written by Shaista Malik
Diabetes Research and Clinical Practice
Objective We examined the extent of control of cardiovascular risk factors and distance from goal for those with uncontrolled levels in a recent sample of U.S. **s with diabetes. Methods In the cross-sectional National Health and Nutrition Examination Survey 2001-2002, 532 (projected to 15.2