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2006-9-2 17:32 | ʾȫ¥ |Ķģʽ

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   ſҩٴϵӦãϸҩԣΪٴѡЧij֣ΪҩҵͻơЧһĻ򲻾пԣ뿹غʱǿĿǰõĿЧҪаड桢-øƼǿȡ
1.аणtrimethoprim TMP
1.1ҩ
   TMPǰҩƣǰҩʱʹϸҶл⵽˫ϣʹǰҩǿʮͬʱǿᡢƽĻءùءùصĿãԴG+һЩG-˫˾ԭͷ߾Ч
1.2 ٴӦ
   ٴϽTMPƼϸȡЧ[1]ȷ֣TMPӶԸ˾־˾ĿԣƶϻTMPԾЧѣ⻹úԴ󳦸˾ŧ˾Ŀãÿ͹ϿĿס
1.3Ӧ֤
   TMPǰ़ǰ׻fãƺȾ·ȾȾĤסѪ֢ȡᡢƽùصƼϸ·Ⱦ׼ƸȾ
1.4÷
   0.1g-0.2gÿΣ12Σͯ5-10mg/kg/գ2ηá
1.5Ӧ
   TMPԽС0.5g/ϣҩԭҶȱӪԻղиȣɳѪ仯ϸѪСȼ١
2.(probenecid)
2.1ҩ
   ɾԵСܶлתˣΪйӦ,50ùͬ,ԼùСܵķڣǿʱ,ѪҩŨ, ϳʱάҩЧù/˫˾ֳǿĿ,Դ˾ϸõĿԡ
2.2ٴӦ
    Ȳնٴо,ʹðù/潺ƼϸԸȾ10450ڰùؽͬ໼50;54Ϊ顣ͶȬЧʾԲ졣ϸΪ86.7%,Բ,ҩΪ71%,ڶ顣ӦΪ5.0%ù/潺һЧȫĿ[2]
2..3Ӧ֤
    ù/Ժϵͳ缱Աס֧ס֧׼֧Ⱦ򼲲ססǰססغŧףȾϸԳסƤ׾нϺЧ
2.4÷
   Ҽùأ194.5mg/棨55.5mgÿ3,ÿ3Ƴ7-14졣
2.5Ӧ
   ҪΪġȸʹθӦ,䷴Ӧ΢˿,账ͣҩ;δѪ,ѪΡܼ쳣
3.-øƼ
   -࿹شӵа͵ʷϸҩԵIJϲƳ˵Ħ-øƼάᣨClavulanic acid̹Sulbactam̹Tazobactamȣ뿹غʱԱزϸĦ-øƻ俹ԡ
3.1ά
3.1.1ҩ
   ά᱾Ϊ-࿹أ俹-࿹ͬΪأ俹ԲǿΪøƼԽϾĦ-ø͹㷺ڳ˾и˾Ϳ˾鵼øǿáάͨø⣬ͬʱҲPBPλŨȵĦ-࿹عͬӰϸ
3.1.2ٴӦ
   Խ[3]о,ӦðĪ/άܲϵͳȾȼ58,ʾȬЧ96.90%,ϸת93.10%(54/58),ϸ95.24%(80 /84),Ⱦ,ֽƬҩMICԣˣоڰĪ,ñȰĪǿ8128
2.1.3Ӧ֤
   άٴҪԺͰĪ֣amoxicillin濨֣TimenlinԼùͷùҩӦΪоµİѪ֢ơǺ͹ؽڡθֳϵͳƤ֯Ӥ׶ĸȾȾԤƿǻȾףЧ밢ĪּӼӽ˺˺ȡýϺЧ
2.1.4÷
   Ī֣0.25磩/άأ0.125gɻ,˼:1-3ÿ,3-4,; עۼ濨֣3g/άأ0.2g˼Ϊ3.2gÿ6-8СʱҩһΣΪÿ4Сʱ3.2g
2.1.5Ӧ
   ĿǰйؿάᵥӦʱӦı밢ĪֵȦ-࿹ӦʱθӦ϶ġкŻ¡ĤԳ׵ȣڷθӦɲͺҩżƤݡпܵ¶ι쳣ҩоֲӦdzԾסطӦʼͣԺߣstevens-johnsonۺƤףιϰȡùعʷ߿ɷݿˡĪ-ά濨-άϸĻҲԵӰ졣
3.2̹
3.2.1ҩ
   ̹ΪҩﵥӦúټЧһֽǿĦ-øƼԽϾͶG+Ħ-øкǿIJã֦-࿹ذùءͷ߾ӦǿԦ-øĿ̹ãֶ԰ϣϾ˾˾Ŀԡ̹백ڲ-øи˾˾˾ϸϾƤȸȾ̹ͷͪãǿͷͪٵȵĻԣʹ俹׸ȫ
3.2.2 ٴӦ
   ChirurgischeѧManncke [4]ڵ¹12ҽԺסԺж̹1gӦ֣4gùأ4gٴЧԼоҩԺãغȾڸȾƤ֯Ⱦ·ȾмЧ1997Marisa [5]ҽԺٴĶҩ˾⿹ԱȽʵ飬о̹백ֶ14ҩ˾8С1997Jimenez [6]̹백ɶҩ˾ĤȡõЧ̩[7]ͷͪ/̹ͷռϸԸȾ182ٴоз֣ƺȾϵȾ128,ҩ66,ҩ62,ȬʷֱΪ72.73%62.90%,ЧʷֱΪ95.45%88.71%;ͷͪ/̹ͷ뿶Ը²ȾȬʷֱΪ72.31%63.93%,ЧʷֱΪ95.38%88.52%;ͷͪ/̹ƲӦΪ4.55%,ͷ뿲ӦΪ6.45%,Ͻͳѧ(P>0.05)ƺȾƤȾ54,ٴȬ64.81%,Ч90.74%ԸϸȾȬЧʷֱΪ67.31%92.31%,ϸΪ92.45%,ӦΪ3.70%ͷͪ/̹,ٴЧ,Ӧ΢,ٴضȺƤ֯ȾһȫЧҩ
2.2.3Ӧ֤
   ̹백֡ͷֵͪãغȾڸȾƤ֯Ⱦ·ȾмЧ
2.2.4÷
    ע֣1g/̹ƣ0.25gÿ3.75gÿ12Сʱ8Сʱ1ΣƳΪ7-14죬ϵͳȾƳ̲5졣עð֣0.5g/̹ƣ0.25g˳üΪÿ1.5-2.5gÿ6-8СʱһΣƳΪ5-14աעͷͪ0.5g/̹ƣ0.5gÿ1-2gÿ12Сʱ1ΣƳΪ7-14졣
2.2.5Ӧ
   ̹֡֡ͷͪδصIJӦ΢ӦƤкASTALT߼۵ȣʹùδѪϵͳϵͳȲӦѪ桢ܵȼָδҩйص쳣ı䣬ٴӦýΪȫ
3.3̹
3.3.1ҩ
   ֺ̹öԶG-G+ЧϾ׸˾Ѫ˾󳦸˾ٵ߾ͳ׳κһͷ߾ءùػ-/-øƼ
2.3.2ٴӦ
    ε[8]/̹ƺϵͳȾ131ȬΪ62.7%ЧΪ89.6%ϸʺϸתʾΪ91.5%ӦΪ11.9%˵/̹СضϸȾȫЧJoshiAlvarezо/̹ԺºȾҲóͬĽ[9-10]
2.3.3Ӧ֤
    ڲø˾ϸŨ˾˾Ⱦºǰ׳⣩Ƥ֯ǻں͸ƸȾԼѪ֢
2.3.4÷
    /̹ĸƼ4g/0.25g4g/0.5gƼΪ4g/0.5gÿ8Сʱ12g/1.5gÿ졣Ӳ鼰Ⱦλԣ16g/2gÿ졣һ㾲ע4g/0.5g3-4졣
2.3.5Ӧ
   ҪǹƤͷȣΪĺ͸к
4.ƥĪ(pidotimod)
4.1 ҩ
   ƥĪ»ѧΪ()-3-[()-(5--2-)ʻ] 4 ,һȫ½ṹרȾߴٽ,ṹڶġڷעõö,ܴٽ߷Ӧܴٽ߷Ӧ[11];ɴٽϸϸɻ,Ȼɱϸ[12];ٽ˿Դܰϸֳ,ʹ߹ܵʱıĸԣϸԣϸıֵָ[13];ͨ**׽ 2ͦøشٽϸ߷Ӧ[14]
4.2 ҩѧ
    ڷƷ800mgѪҩŨȴʱΪ2.42hƽŨΪ4.37ug/ml˥Ϊ2hƽAUCΪ21.17ug/ml.hڷöԼΪ45%
4.3ٴӦ
   ʵ֤ʵƥĪڻ忹Ⱦ߷ӦеĶϾǿáƥĪ¾ֱӵĿãͨ߻ԴԿȾܴﵽƸȾԼĿġƥĪʹãɴԴԴ;ƸȾЧڳ濹ƷٴڷֹͯĺȾ(ңң)֧סȾƶȾȡĽ[15-17]Pozzi[18]137֧׻ӦƥĪ½иƣͬʱʹðĪ/άĻϣʵƥĪ0.8gһնΣʾʵƽʱΪ8.9죬ڰο飨10.7죩Ժ,Ӧʵ͡
4.4Ӧ֤
   ƷȿɵʹãԤȾڲ֢̲̣ἲضȣٷҲΪԸȾʱҩĸƣ߿ҩЧʹʱƥĪ¿ƷºȾס֧ססססж׵ȣϵͳȾƸȾԲѪҺߵĸȾԤȾԸȾ˿ƸȾȡ
4.5÷
   ˼ҩʼÿ0.8gһնΣΪÿ0.8gһһΡԤҩÿ0.8gһһΡͯ롣
4.6Ӧע
    ƥĪ°ȫԸߣ˼ͯáټIJӦͷʹġŻ¡ʹкƤȣһͣҩ
ԱƷߺ3ڸŮáʳӰ챾ƷգʱƷӦڲǰͺ2Сʱҷá
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