2.脉冲琼脂电泳(pulsed-field gel electrophoresis,PFGE):尽管PFGE已经代替质粒图谱(技术复杂)作为RGM DNA指印的主要方法,但约有50%的龟分枝杆菌脓肿亚种通过此法不能得到正确的结果[2,13]。Lai等[11]采用DraⅠ、XbaⅠ、AseⅠ和SpeⅠ消化龟分枝杆菌脓肿亚种染色体总DNA,进行PFGE,其结果不令人满意。Zhang等[10]采用DraⅠ、XbaⅠ或AsnⅠ消化龟分枝杆菌染色体总DNA,进行PFGE,结果***龟分枝杆菌龟亚种PFGE图谱尚可,但118株龟分枝杆菌脓肿亚种只有46株结果令人满意。
2,Villanueva A,Calderon RV,Vargas B,et al. Report on an outbreak of postinjection abscesses due to Mycobacterium abseceeus,including management with surgery and claritromycin therapy and comparison of strains by random amplified polymorphic DNA polymerase chain reaction.Clin Infect Dis,1997,24:1147-1153.
4,Singh N,Yu L.Successful treatment of pulmonary infection due to mycobacterium chelonae:case report and review.Clin Infect Dis, 1992,14:156-161.
5,熊礼宽.编著.结核病的实验室诊断及其进展.北京:中国科学技术出版社,1992:3-73.
6,Conville PS, Witebsky FG. Variables affecting results of sodium chloride tolerance test for identification of rapidly growing mycobacteria.J Clin microbil,1998,36:1555-1559.
7,Wallace RJJAr, Silcox VA, Tsukamura M, et al.Clinical significance,biochemical features,and susceptibility patterns isolates of the mycobacterium chelonae-like organism.J Clin Microbiol,1993,31:3231-3239.
8,Bosne S, Levy-Frebault VV. Mycobactin **ysis as an aid for the identification of Mycobacterium fortuitum and Mycobacterium chelonae subspecies.J Clin Microbiol,1992,30:1225-1231.
9,Linton CJ,Jalal H,Leeming JP ,et al.Rapid discrimination of Mycobacterium tuberculosis strains by random amplified polymorphic DNA **ysis.J Clin microbiol, 1994,32:2169-2174.
10,Zhang Y, Rajagopalan M,Brown BA,et al.Randomly amplified polymorphic DNA pCR for comparison of Mycobacterium abscessus strains form nosocomial outbreaks.J Clin Microbiol, 1997,35:3132-3139.
11,Lai K, Brown BA, Westerling JA, et al. Long-term laboratory contamination by Mycobacterium abscessus resulting in two pseudo-outbreaks:recognition with use of random amplified polymorphic DNA(RAPD) polymerase chain reaction. Clin infect Dis, 1998,28:169-175.
12,Yingzhou Y, Likuan X. Randomly amplified polymorphic DNA PCR of mycobacterium abscessus strains. 20th Eastern Region Conference of the international Union Against tuberculosis & Lung Disease, 1999, 185.
13,Wallace RJ JAr, Zhang Y,Brown BA,et al.DNA large restriction fragment patterns of sporadic and epidemic nosocomial strains of Mycobacterium chelonae and Mycobacterium abscessus. J Clin Microbiol, 1993,31:2697-2701.
14,Wilson RW,Steingrube VA, Brown BA, et al. Clinical application of PCR-restriction enzyme pattern **ysis for rapid identification of aerobic actinomycete isolates. J Clin Microbil, 1998,36:148-152.
15,Steingrube VA,Gibson JL, Brown BA, et al. PCR amplification and restrication endonuclease **ysis of a 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria.J Clin microbiol,1995,33:149-153.
16,Wallace RJ, Brown BA, Onyi GO. Susceptibilities of Mycobacterium fortuitum biovar. fortuitum and the two subgroups of Mycobacterium chelonae to imipenem, cefmetazole, cefoxitin, and amoxicillin-clavulanic acid. Antimicrob Agents chemother, 1991,35:773-775.
17,Wallace RJ,Meier A, Brown BA,et al.Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. antimicrob Agents Chemother, 1996, 40:1676-1681.
19,Hoffner SE,Klintz L, Olsson-Liljequist B,et al.Evaluation of Etest for rapid susceptibility testing of Mycobacterium chelonae and M.fortuitum.J Clin microbiol,1994,32:1846-1849.
20,Woods GL, Bergmann JS,Witebsky FG,et al.Multisite reproducibility of results obtained by the broth microdilution method for susceptbility testing of mycobacterium abscessus, Mycobacterium chelonae,and Mycobacterium fortuitum. J clin Microbiol,1999,37:1676-1682.