婴幼儿暂时性高磷酸酶血症( transient hyperphosphatasemia of infancy and early childhood,THI)是指婴幼儿在无肝或骨疾病的情况下其血清碱性磷酸酶(ALP)活性呈暂时、孤立的显著升高[1-3].根据Ilham等[4]记载,该病于1954年首先由Bach等描述.于1977年Posen等[5]首次将其命名为婴儿暂时性高磷酸酶血症.直到1985年,Kraut等[6]才确立THI的诊断标准.THI在婴幼儿可能是一种相对常见状况[2].通常在健康或患轻微疾病的儿童中偶然被发现。THI患儿的显著特征是其血清碱性磷酸酶(ALP)活性异常升高,且ALP活性一般在数月内可自行恢复至正常水平。THI并不威胁患者的生命,是一种良性现象,其预后良好。现对THI的病因、发病机制以及诊疗等方面的研究进展进行综述,旨在加深对THI的认识,从而避免对其误诊误治。
婴幼儿暂时性高碱性磷酸酶血症(transient hyperphosphatasemia of infancy and early childhood,THI)是指婴幼儿在无肝或骨疾病的情况下其血清碱性磷酸酶活性呈暂时、孤立的显著升高[7]。该病于1954年首先由Bach[8]等描述。有研究显示[9]:儿童中暂时性高碱性磷酸酶血症的发生率可能超过2.8%。THI绝非是一种罕见现象,是一种相对常见的情况。例如,Suzuki[10]等经过对19230份儿童血清样本筛查,最后确诊为THI的竟达50例之多。发病年龄大多数在5岁以下[11]。THI在成人也偶有发生[12]。
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