标题: 清痹颗粒对Ⅱ型胶元蛋白诱导大鼠关节炎模型的影响 [打印本页] 作者: liuxuli007 时间: 2008-8-23 17:02 标题: 清痹颗粒对Ⅱ型胶元蛋白诱导大鼠关节炎模型的影响 [摘要]目的:考察清痹颗粒对大鼠Ⅱ型胶原性关节炎(CIA) 相关免疫学指标的影响。方法:用Ⅱ型胶原(CⅡ)加完全佛氏佐剂(CFA)免疫Wistar大鼠建立胶原诱导性关节炎(CIA)模型,给药后,检测血清中CⅡ抗体、TNF-α,组织中IL-2水平,脾细胞中TNF-α。结果:清痹颗粒显著降低关节周围组织的白介素-2水平,显著降低模型大鼠Ⅱ型胶原蛋白抗体水平,降低模型大鼠肿瘤坏死因子水平,清痹颗粒对风湿性关节炎有较好的治疗作用。
[关键词]清痹颗粒;Ⅱ型胶原蛋白;类风湿性关节炎
Effect of QingBi-particles on Wistar rats arthritis model induced by the Ⅱ-type collagen protein
Liu Xu-li
(Combination Speciality of Medicine, Grade 2003, 20033017)
[Abstract]Objective: Studying the effect of Qing Bi-particles on related index of immunology in Ⅱ-type CIA wistar-rats. Methods: Wistar rats CIA model was induced by the combination of Ⅱ-type collagen protein and CFA. After administration, test the levels of Ⅱ-type collagen protein antibody and TNF-αof blood-serum, IL-2 of tissues, TNF-α of splenic cells. Results: The IL-2 level of arthrosis circum-tissues was decreased significantly,the level of Ⅱ-type collagen protein antibody was was also decreased significantly as the above. And the tumor necrosis factor level of the handled rats was decreased by QingBi-particles. So, there was a better effect of QingBi-particles on rheumarthritis.
[Key words]Qing Bi-particles; Ⅱ-type collagen protein; rheumatoid arthritis