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虽然Brugada两兄弟于1992年确定了此类患者的临床特点,但在此之前,早已有相应的临床报道,尤其是在东南亚。1976到1977年,美国疾病控制预防中心(CDC)观察到,在越南战争结束时,大批**到美国的老挝、柬埔寨难民中的年轻男性,存在不寻常的高死亡率,CDC将此定义为存在于东南亚人的难以解释的猝死综合征(suddden unexplained death syndrome,SUDS)[10]。1981~1982年,死亡率上升至高峰,达25/10万。他们平均年龄为32岁(16~63岁),大多为男性,68%的死亡者来自老挝,18%来自柬埔寨,13%来自越南。虽然1977年CDC才注意到这种综合征,但在亚洲已发现多年。在菲律宾叫做“Bargungut”,在日本叫做“Pokkuki”,泰国叫做“Laitai”,所有这些名词的意思为“夜间睡眠中的死亡”,绝大多数发生在年轻人。在地理位置分布上,泰国、老挝、柬埔寨、越南和菲律宾是流行发病区。此综合征在泰国最普遍,在泰国东北部,年死亡率在40/10万[10,11],为该地区年轻人第二位死亡原因,仅次于第一位的交通事故。在该地区70年前就已有类似于老挝**至美国的猝死表现的患者。最近在中国人群中陆续也有相似报道[12,13]。
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