Mining the Wnt pathway for cancer therapeutics。
Nick Barker and Hans Clevers
Abstract | Aberrant activation of the Wnt pathway is implicated in driving the formation of various human cancers, part<!--HAODF:2:DE4r0u-lSI6Bfz46fy9waRQsfzPify4-->icu<!--HAODF:/2:DE4r0u-lSI6Bfz46fy9waRQsfzPify4-->larly those of the digestive tract. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Here we provide an
overview of the promise and pitfalls of current drug development strategies striving to inhibit the Wnt pathway and present new opportunities for therapeutic intervention.
此附件已经损坏等待作者修复作者: 灵舞起舞 时间: 2007-2-19 22:36
谢谢，我收了，但压缩2打不开。